Pyrroloquinoline Quinone (PQQ) is a small quinone molecule with vitamin-like properties like the Dihexa (PNB-0408) powder. The compound is a potent redox agent doubling as an antioxidant. Therefore, it is extremely stable and pharmacologically significant in the treatment of neurodegeneration.
Several clinical studies confirm pyrroloquinoline quinone (PQQ) to be powerful than typical vitamin C antioxidants such as ascorbic acid and epicatechin.
This mineral is naturally synthesized in various plants. Some of the Pyrroloquinoline quinone food sources include papaya, kiwi fruit, green tea, soybeans, parsley, and green pepper. Though the compound may seem nonessential nutrient in human nutrition, its presence in the mammalian system proves to have notable health gains.
The pyrroloquinoline quinone benefits mitochondrial functionality. The efficiency of these organelles ensures optimal cell energy, including cellular growth and survival.
The mechanism of action of PQQ is synonymous with that of Dihexa (PNB-0408) powder. The product binds to and modifies the activity of quinoproteins in the human body. It is a potent anti-oxidant, which works to get rid of free radicals within the cells. The compound is 100x more effective than vitamin C.
In preclinical studies with murine models, Pyrroloquinoline quinone powder (72909-34-3) inflammation drug stimulates the massive production of mitochondria for the optimal functioning of the cell. This compound interacts with the cell signaling pathways, which enhance mitochondrial biogenesis.
Exposure to Pyrroloquinoline quinone disodium salt improves the energy expenditure while decreasing plasma triglycerides. It relieves cardiac ischemia and alleviates neuronal loss and cell death.
I. Improves Mitochondrial Function
Mitochondrial dysfunction has been the root cause of most neurodegenerative diseases such as Alzheimer’s, multiple sclerosis, Parkinson’s syndrome, and cancer progression.
Therefore, it is obvious and more practical to power up the efficiency of mitochondria rather than doctoring the symptoms of these diseases. Taking PQQ Alzheimer’s supplement will fire up the generation of mitochondria. Over the years, dietary supplements and pharmaceutical drugs have proved to be promising for boosting the density and efficacy of this cell organelle. One of the groundbreaking inventions was the discovery of pyrroloquinoline quinone.
Besides, it alleviates oxidative stress within the cellular tissues. Therefore, PQQ can be a silent anti-aging compound, which improves cognition and memory, while reversing neuronal disorders associated with senescence.
II. Improves Nerve Growth Factors (NGF)
When PQQ interacts with the cellular pathways, it always leaves a positive impact on the nerve growth factors by enhancing their progression. It ensures the survival and development of the neuronal cells. Consequently, there’s protection of the neurons and the production of nerves in the cranial tissues. We can, therefore, infer that pyrroloquinoline quinone disodium salt improves higher brain function.
Clinicians have been linking NGF dysregulation with Alzheimer’s disease. Therefore, Pyrroloquinoline quinone may be the ideal antidote for this age-related condition.
III. Prevents Oxidative Stress
Oxidative stress is responsible for major chronic illnesses such as neurodegenerative diseases and some carcinomas.
PQQ sets in to attenuate the oxidative damage that results from free radicals, and boosts the metabolism of energy, thanks to its antioxidant properties. Pyrroloquinoline quinone disodium decreases the levels of IL-6 and C-Reactive Protein, which are contributing markers of inflammation.
Pyrroloquinoline quinone disodium salt improves higher brain function, cognition, memory, and attention. Efficiency in the mitochondrial functions guarantees a healthy lifestyle that’s free from neurodegenerative diseases.
In a clinical study involving 41 elderly subjects, the scholars established that PQQ could boost cognition, prevent memory loss, and improve attention.
V. Improves Lipid Metabolism
In a certain preclinical study, the murine models with Pyrroloquinoline quinone disodium deficiency had low metabolic rates and high levels of triglycerides. Conversely, the rats with normal Pyrroloquinoline quinone levels had healthy levels of cholesterol, triglycerides, blood pressure, and adiposity.
Besides being neuroprotective, PQQ is also cardioprotective. Individuals taking the substance are less likely to suffer from cardiac injury due to ischemia or reperfusion.
Other notable Pyrroloquinoline quinone benefits are sleep enhancement and an increase in fertility and reproduction.
Plants have proved to be the ultimate source of Pyrroloquinoline quinone (PQQ). Although animal foods such as eggs and dairy fall in this category, some scientists have brushed them off as mere speculations. The detection method is under question since the mammalian cells cannot produce Pyrroloquinoline quinone. Scholars suppose that the content of PQQ in the human tissue originates from diet or the enteric bacterial production.
PQQ has a short half life of between three and five hours. Therefore, it works at a rate of knots. In rats, administering Pyrroloquinoline quinone supplement increased up to 20% of the cellular mitochondria by the second day.
Some significant changes may be visible after six months. A flip through the Pyrroloquinoline quinone Reddit reviews confirm that users prefer stacking the supplement with CoQ-10 or ubiquinol.
Adverse Pyrroloquinoline quinone side effects are quite sporadic especially if you stick to the standard 20-40mg daily dose with short-term use. Humans ought not to exceed one year of consistent usage.
Typical PQQ dangers include headaches, fatigue, and drowsiness. Some users also report hypersensitivity and insomnia.
Well, you should be blissful that the compound has no adverse side effects. However, ensure to embrace a low dosage as a key Pyrroloquinoline quinone safety measure.
Since Pyrroloquinoline quinone powder has not received full approval by the Federal Drug Administration for medicinal use, there’s no standard dosage.
Pyrroloquinoline quinone dosage ranges between 20-40mg per day. The dose hinges on whatever condition you are managing. For instance, when increasing the mitochondria count, you may only need less than a milligram of Pyrroloquinoline quinone disodium salt per day. However, the dose escalates up to 20mg when treating inflammation.
The supplement is available for oral administration. Therefore, you will require one to two capsules per day, preferably on an empty stomach.
Although there are no known grave Pyrroloquinoline quinone side effects, you must stick to the above dosage. You should not exceed 80mg in a single day lest you fall out with the PQQ dangers.
Pyrroloquinoline quinone supplement is up for sale in online stores and physical shops. Although virtual shopping is convenient as you get to compare prices and see real-time reviews, I recommend vigilance, should you fall prey to fake supplements.
Co-founder, the company’s core administration leadership; PhD received from Fudan University in organic chemistry. More than nine years of experience in organic synthesis field of medicinal chemistry. Rich experience in combinatorial chemistry, medicinal chemistry and custom synthesis and project management.